IBBiology @Skyline High School

                                                                                                                                                                     

 

Cell Cycle and DNA Replication (11 days)

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Assessment Statements:

2.5.1

Outline the stages in the cell cycle, including interphase (G1, S, G2), mitosis and cytokinesis.

 

2.5.2

State that tumours (cancers) are the result of uncontrolled cell division and that these can occur in any organ or tissue.

 

2.5.3

State that interphase is an active period in the life of a cell when many metabolic reactions occur, including protein synthesis, DNA replication and an increase in the number of mitochondria and/or chloroplasts.

 

2.5.4

Describe the events that occur in the four phases of mitosis (prophase, metaphase, anaphase and telophase).

 

2.5.5

Explain how mitosis produces two genetically identical nuclei.

 

2.5.6

State that growth, embryonic development, tissue repair and asexual reproduction involve mitosis.

 

 

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What You Need to Know

Cell Cycle

Chromatin vs. chromosomes – what is difference, when is it found in the cell?

Why the cell must divide to create more cells?

Sketch and describe the process of binary fission.  In what type of cells does it occur?

What are the three phases of the cell cycle in eukaryotic cells? 

What percent of the cell cycle does interphase make up? 

What happens during the G1, S and G2 phases of interphase? 

Sketch and describe the events happening during each phase of mitosis, including descriptions of the amount of DNA and chromosomes in the cell

What are kinetochores and kinetochore microtubules?

How is cytokinesis different between plant and animal cells? 

In animal cells, how is the cleavage furrow formed?  In plant cells, how is the cell plate formed?

 

Cancer

Define cancer, tumor and metastasis.

Contrast benign and malignant tumors.

Describe how cancer arises, referring to accumulation of mutations over time.

What is the function of a proto-oncogene?

What is the relationship between proto-oncogenes and oncogenes?

Describe the role of tumor suppressors?

How are cancer cells different than normal cells in terms of density dependency, anchorage dependency and the number of divisions that a cell can go through? 

 

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Unit Activities List:

Unit overview sheet (pdf)

Mitosis web quest (pdf)

Stages of mitosis puzzle (doc)

Modeling mitosis with pipe cleaners (doc)

Cell cycle class notes (doc)

Mitosis drawing lab

Mitosis stop action videos

Inside cancer reading

End of life video

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Key Terms:

anaphase

binary fission

cell plate

centromere

chromatid

chromatin

chromosome

cleavage furrow

cytokinesis

interphase

kinetochore

kinetochore microtubule

metaphase

mitosis

nuclear envelope

nucleolus

prophase

S phase

spindle

telophase

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Helpful Links:

Cell Cycle

Mitosis with Music

Cell Cycle Game (CDK's and cyclins)

Cell Death

Cell Cycle and Cyclins + Other Cellular Activities

DNA Coiling to form Chromosomes

The Cell Cycle

How Cells Divide

 

Cancer

Biochemical Pathways of Normal and Cancer Cells

Breast Cancer

Cancer Biology and Cell Technology

The Biology of Cancer

Cell Biology and Cancer

Cancer and the Cell Cycle

Cancer Warrior

Cancer Quest

Insidecancer.org

p53: The Guardian of the Genome

Second Cancers

Cancer Biology

How Cancer Grows

 

 

"When we tug at a simple thing in nature, we find it attached to the rest of the world."  John Muir