Essential Idea:  Immunity is based on recognition of self and destruction of foreign material.

• Outline answer to each objective statement for topic 11.1 (coming soon)
• Quizlet study set for this topic (coming soon)

At SHS, Topic 11.1 is taught in the following class unit(s):​​​​​​​​​​​​​​​

• Acquired Immunity

Statements & Objectives:

11.1.U1  Every organism has unique molecules on the surface of its cells.

• Define antigen.
• List example antigen molecules.

11.1.U2  B lymphocytes are activated by T lymphocytes in mammals.

• Explain the “challenge and response” mechanism of specific immunity.
• Describe activation of helper T lymphocytes by the macrophage.
• Describe activation of B cell lymphocytes by the helper T cells.​

11.1.U3  Plasma cells secrete antibodies.

• Outline the structure and function of plasma B cells.​

11.1U4  Activated B cells multiply to form clones of plasma cells and memory cells.

• Describe clonal selection of plasma B cells.​

11.4.U5  Antibodies aid the destruction of pathogens.

• Outline four modes of antibody action.​

11.1.U6  Immunity depends upon the persistence of memory cells.

• Define immunity.
• State two mechanisms of immunity.
• Explain the differences between the primary and secondary immune responses.

11.1.U7  Vaccines contain antigens that trigger immunity but do not cause the disease.

• Explain the principle of vaccination.​

11.1.U8  Pathogens can be species-specific although others can cross species barriers.

• Outline mechanisms that prevent some pathogens from crossing species.
• Define zoonosis.
• List three examples of zoonotic diseases.

11.1.U9  White cells release histamine in response to allergens.

• State the source and function of histamine proteins.

11.1.U10  Histamines cause allergic symptoms.

• List allergic symptoms caused by histamines.
• State the function of an anti-histamine.​

11.1.U11  Fusion of a tumor cell with an antibody-producing plasma cell creates a hybridoma cell.

• Explain the production of hybridoma cells.

11.1.U12  Monoclonal antibodies are produced by hybridoma cells.

• Define “monoclonal antibody.”
• Describe the production of monoclonal antibodies in hybridoma cells.

• Outline the use of monoclonal antibodies in diagnosis and treatment.​

11.1.A1  Antigens on the surface of red blood cells stimulate antibody production in a person with a different blood group.

• Outline the difference between the ABO blood antigens.
• State the fours human ABO blood types.
• Describe the consequence of mismatched blood transfusions, including agglutination and hemolysis.

11.1.A2  Smallpox was the first infectious disease of humans to have been eradicated by vaccination.

• Describe the global initiative used to eradicate smallpox.​

11.1.A3  Monoclonal antibodies to HCG are used to pregnancy test kits.

• Describe a pregnancy test strip works, including the role of free and immobilized monoclonal antibodies.

11.1.S1  Analysis of epidemiological data related to vaccination programs.

• Define epidemiology.
• Outline the role of an epidemiologist in vaccination programs.

11.1.NOS  Consider ethical implications of research- Jenner tested his vaccine for smallpox in a child.

• Describe how Jenner tested his smallpox vaccine.
• List reasons when Jenner’s test would not be approved today.