8.1.U1 Metabolic pathways consist of chains and cycles of enzyme-catalyzed reactions.
Contrast metabolic chain reaction pathways with cyclical reaction pathways.
8.1.U2 Enzymes lower the activation energy of the chemical reactions that they catalyze.
Define activation energy.
Explain the role of enzymes in lowering the activation energy of a reaction.
8.1.U3 Enzyme inhibitors can be competitive or non-competitive.
Define enzyme inhibitor.
Contrast competitive and noncompetitive enzyme inhibition.
Outline one example of a competitive enzyme inhibitor and one example of a noncompetitive enzyme inhibitor.
8.1.U4 Metabolic pathways can be controlled by end-product inhibition.
Describe allosteric regulation of enzyme activity.
Outline the mechanism and benefit of end-product inhibition.
8.1.A1 End-product inhibition of the pathway that converts threonine is isoleucine.
Illustrate end-product inhibition of the threonine to isoleucine metabolic pathway.
State the consequence of an increase in isoleucine concentration.
8.1.A2 Use of databases to identify potential new anti-malarial drugs.
Outline the reasons for development of new anti-malarial drugs.
Explain the use of databases in identification of potential new anti-malarial drugs.
8.1.S1 Distinguish different types of inhibition from graphs at specified substrate concentration.
Explain why the rate of reaction with increasing substrate concentration is lower with a non-competitive inhibitor compared to a competitive inhibitor.
8.1.S2 Calculating and plotting rates of reaction from raw experimental results.
State two methods for determining the rate of enzyme controlled reactions.
State the unit for enzyme reaction rate.
Given data, calculate and graph the rate of an enzyme catalyzed reaction.
8.1.NOS Developments in scientific research follow improvements in computing- developments in bioinformatics, such as the interrogation of databases have facilitated research into metabolic pathways.
Outline the use and benefits of the bioinformatics technique of chemogenomics in development of new pharmaceutical drugs.
I give many of my IB Biology resources away, for the benefit of students and teachers around the world. If you've found the materials helpful, please consider making a contribution of any amount to this Earthwatch Expedition Fund.
Did I forget something? Know of a mistake? Have a suggestion? Let me know by emailing me here.
Before using any of the files available on this site, please familiarize yourself with the Creative Commons Attribution License. It prohibits the use of any material on this site for commercial purposes of any kind.