Essential Idea: Metabolic reactions are regulated in response to the cell’s needs.
- Outline answer to each objective statement for topic 8.1 (coming soon)
- Quizlet study set for this topic (coming soon)
At SHS, Topic 8.1 is taught in the following class unit(s):
8.1.U1 Metabolic pathways consist of chains and cycles of enzyme-catalyzed reactions.
- Contrast metabolic chain reaction pathways with cyclical reaction pathways.
8.1.U2 Enzymes lower the activation energy of the chemical reactions that they catalyze.
- Define activation energy.
- Explain the role of enzymes in lowering the activation energy of a reaction.
8.1.U3 Enzyme inhibitors can be competitive or non-competitive.
- Define enzyme inhibitor.
- Contrast competitive and noncompetitive enzyme inhibition.
- Outline one example of a competitive enzyme inhibitor and one example of a noncompetitive enzyme inhibitor.
8.1.U4 Metabolic pathways can be controlled by end-product inhibition.
- Describe allosteric regulation of enzyme activity.
- Outline the mechanism and benefit of end-product inhibition.
8.1.A1 End-product inhibition of the pathway that converts threonine is isoleucine.
- Illustrate end-product inhibition of the threonine to isoleucine metabolic pathway.
- State the consequence of an increase in isoleucine concentration.
8.1.A2 Use of databases to identify potential new anti-malarial drugs.
- Outline the reasons for development of new anti-malarial drugs.
- Explain the use of databases in identification of potential new anti-malarial drugs.
8.1.S1 Distinguish different types of inhibition from graphs at specified substrate concentration.
- Explain why the rate of reaction with increasing substrate concentration is lower with a non-competitive inhibitor compared to a competitive inhibitor.
8.1.S2 Calculating and plotting rates of reaction from raw experimental results.
- State two methods for determining the rate of enzyme controlled reactions.
- State the unit for enzyme reaction rate.
- Given data, calculate and graph the rate of an enzyme catalyzed reaction.
8.1.NOS Developments in scientific research follow improvements in computing- developments in bioinformatics, such as the interrogation of databases have facilitated research into metabolic pathways.
- Outline the use and benefits of the bioinformatics technique of chemogenomics in development of new pharmaceutical drugs.